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Definition Acrocyanosis is a decrease in the amount of oxygen delivered to the extremities. The hands and feet turn blue because of the lack of oxygen. Decreased blood supply to the affected areas is caused by constriction or spasm of small blood vessels. Description Acrocyanosis is a painless disorder caused by constriction or narrowing of small blood vessels in the skin of affected patients. The spasm of the blood vessels decreases the amount of blood that passes through them, resulting in less blood being delivered to the hands and feet. The hands may be the main area affected. The affected areas turn blue and become cold and sweaty. Localized swelling may also occur. Emotion and cold temperatures can worsen the symptoms, while warmth can decrease symptoms. The disease is seen mainly in women and the effect of the disorder is mainly cosmetic. People with the disease tend to be uncomfortable, with sweaty, cold, bluish colored hands and feet. Causes and symptoms The sympathetic nerves cause constriction or spasms in the peripheral blood vessels that supply blood to the extremities. The spasms are a contraction of the muscles in the walls of the blood vessels. The contraction decreases the internal diameter of the blood vessels, thereby decreasing the amount of blood flow through the affected area. The spasms occur on a persistent basis, resulting in long term reduction of blood supply to the hands and feet. Sufficient blood still passes through the blood vessels so that the tissue in the affected areas does not starve for oxygen or die. Mainly, blood vessels near the surface of the skin are affected. Diagnosis Diagnosis is made by observation of the main clinical symptoms, including persistently blue and sweaty hands and/or feet and a lack of pain. Cooling the hands increases the blueness, while warming the hands decreases the blue color. The acrocyanosis patient's pulse is normal, which rules out obstructive diseases. Raynaud's disease differs from acrocyanosis in that it causes white and red skin coloration phases, not just bluish discoloration. Treatment Acrocyanosis usually isn't treated. Drugs that block the uptake of calcium (calcium channel blockers) and alpha-one antagonists reduce the symptoms in most cases. Drugs that dilate blood vessels are only effective some of the time. Sweating from the affected areas can be profuse and require treatment. Surgery to cut the sympathetic nerves is performed rarely. Prognosis Acrocyanosis is a benign and persistent disease. The main concern of patients is cosmetic. Left untreated, the disease does not worsen. Key Terms - Sympathetic nerve
- A nerve of the autonomic nervous system that regulates involuntary and automatic reactions, especially to stress.
For Your Information Books - Alexander, R. W., R. C. Schlant, and V. Fuster, eds. The Heart. 9th ed. New York: McGraw-Hill, 1998.
- Berkow, Robert, ed. Merck Manual of Medical Information. Whitehouse Station, NJ: Merck Research Laboratories, 1997.
- Larsen, D. E., ed. Mayo Clinic Family Health Book. New York: William Morrow and Co., Inc., 1996.
Source: Gale Encyclopedia of Medicine, Published December, 2002 by the Gale Group
The Essay Author is John T. Lohr PhD.
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