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Definition Erythema multiforme is a skin disease that causes lesions and redness around the lesions. Description Erythema multiforme appears on the skin and the mucous membranes (the lining of the mouth, digestive tract, vagina, and other organs). Large, symmetrical red blotches appear all over the skin in a circular pattern. On mucous membranes, it begins as blisters and progresses to ulcers. A more advanced form, called Stevens-Johnson syndrome, can be severe and even fatal. Causes and symptoms Erythema multiforme has many causes, most commonly are drugs. Penicillin, sulfonamides, certain epilepsy drugs, aspirin, and acetaminophen are the most likely medication-induced causes. Erythema multiforme can also be caused by certain diseases. Herpes virus and mycoplasma pneumonia are likely infectious causes. Diagnosis The appearance of the rash is sufficiently unique to identify it on sight. Having identified it, the physician will determine the underlying cause. Treatment Erythema multiforme is inadvertently treated when the causative agent, whether it be a drug or a disease, is treated. In severe cases, cortisone-like medication is often used along with general supportive measures and prevention of infection. Prognosis As a rule, the rash abates by itself without damaging the skin. Only in the case of infection, severe blistering, or continued use of an offending drug does complications occur. Key Terms - Herpes virus
- Viruses that can infect the skin, mucous membranes, and brain, and they are responsible for such diseases as herpes simplex, chicken pox, and shingles.
- An incomplete bacterium that infects the lung.
For Your Information Books - Bennett, J. Claude, and Fred Plum, eds. Cecil Textbook of Medicine. Philadelphia: W. B. Saunders Co., 1996.
- Current Medical Diagnosis and Treatment, 1996. 35th ed. Ed. Stephen McPhee, et al. Stamford: Appleton & Lange, 1995.
- Fritsch, Peter O., and Peter M. Elias. "Erythema Multiforme and Toxic Epidermal Necrolysis." In Dermatology in General Medicine, ed. Thomas B. Fitzpatrick, et al. New York: McGraw-Hill, 1993.
- Harrison's Principles of Internal Medicine. Ed. Anthony S. Fauci, et al. New York: McGraw-Hill, 1997.
Source: Gale Encyclopedia of Medicine, Published December, 2002 by the Gale Group
The Essay Author is J. Ricker Polsdorfer MD.
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