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Definition Q fever is an illness caused by a type of bacteria, Coxiella burnetii, resulting in a fever and rash. Description C. burnetii lives in many different kinds of animals, including cattle, sheep, goats, ticks, cats, rabbits, birds, and dogs. In sheep and cattle, for example, the bacteria tends to accumulate in large numbers in the female's uterus (the organ where lambs and calves develop) and udder. Other animals have similar patterns of bacterial accumulation within the females. As a result, C. burnetii can cause infection through contaminated milk, or when humans come into contact with the fluids or tissues produced when a cow or sheep gives birth. Also, the bacteria can survive in dry dust for months; therefore, if the female's fluids contaminate the ground, humans may become infected when they come in contact with the contaminated dust. Persons most at risk for Q fever include anybody who works with cattle or sheep, or products produced from them. These include farm workers, slaughterhouse workers, workers in meat-packing plants, veterinarians, and wool workers. Q fever has been found all over the world, except in some areas of Scandinavia, Antarctica, and New Zealand. Causes and symptoms C. burnetii causes infection when a human breathes in tiny droplets, or drinks milk, containing the bacteria. After three to 30 days, symptoms of the illness appear. The usual symptoms of Q fever include fever, chills, heavy sweating, headache, nausea and vomiting, diarrhea, fatigue, and cough. Also, a number of other problems may present themselves, including inflammation of the liver (hepatitis); inflammation of the sac containing the heart (pericarditis); inflammation of the heart muscle itself (myocarditis); inflammation of the coverings of the brain and spinal cord, or of the brain itself (meningoencephalitis); and pneumonia. Chronic Q fever occurs most frequently in patients with other medical problems, including diseased heart valves, weakened immune systems, or kidney disease. Such patients usually have about a year's worth of vague symptoms, including a low fever, enlargement of the spleen and/or liver, and fatigue. Testing almost always reveals that these patients have inflammation of the lining of the heart (endocarditis). Diagnosis Q fever is diagnosed by demonstrating that the patient's immune system is making increasing numbers of antibodies (special immune cells) against markers (antigens) that are found on C. burnetii. Treatment Doxycycline and quinolone antibiotics are effective for treatment of Q fever. Treatment usually lasts for two weeks. Rifampin and doxycycline together are given for chronic Q fever. Chronic Q fever requires treatment for at least three years. Prognosis Death is rare from Q fever. Most people recover completely, although some patients with endocarditis will require surgery to replace their damaged heart valves. Prevention Q fever can be prevented by the appropriate handling of potentially infective substances. For example, milk should always be pasteurized, and people who work with animals giving birth should carefully dispose of the tissues and fluids associated with birth. Industries which process animal materials (meat, wool) should take care to prevent the contamination of dust within the plant. Vaccines are available for workers at risk for Q fever. Key Terms - Antibodies
- Specialized cells of the immune system that can recognize organisms that invade the body (such as bacteria, viruses, and fungi). The antibodies are then able to set off a complex chain of events designed to kill these foreign invaders.
- Antigens
- Markers on the outside of bacteria or viruses which can be recognized by antibodies.
- Immune system
- The system of specialized organs, lymph nodes, and blood cells throughout the body which work together to prevent foreign invaders (bacteria, viruses, fungi, etc.) from taking hold and growing.
- Inflammation
- The body's response to tissue damage. Includes increased heat, swelling, redness, and pain in the affected part.
For Your Information Books - Corey, Lawrence. "Rickettsia and Coxiella." In Sherris Medical Microbiology: An Introduction to Infectious Diseases. 3rd ed. Ed. Kenneth J. Ryan. Norwalk, CT: Appleton & Lange, 1994.
- Walker, David, et al. "Rickettsial Diseases." In Harrison's Principles of Internal Medicine, ed. Anthony S. Fauci, et al. New York: McGraw-Hill, 1997.
Periodicals- "Q Fever Outbreak: Germany, 1996." Morbidity and Mortality Weekly Report 46, no. 2 (17 Jan. 1997): 29+.
- Valero, Frank. "Pericardial Effusion as the Initial Feature of Q Fever." American Heart Journal 130, no. 6 (Dec. 1995): 1308+.
Organizations- Centers for Disease Control and Prevention. 1600 Clifton Rd., NE, Atlanta, GA 30333. (800) 311-3435, (404) 639-3311. http://www.cdc.gov
Source: Gale Encyclopedia of Medicine, Published December, 2002 by the Gale Group
The Essay Author is Rosalyn Carson-DeWitt MD.
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